All concepts, explanations, trials, and studies have been re-written in plain English and may contain errors. I am not a doctor ----------------------------------------------------------- INTRODUCTION The independent prognostic value of elevated jugular venous pressure or a third heart sound in patients with heart failure is not well established. METHODS We analyzed SOLVD trial data, in which 2,569 CHF patients were randomly assigned to take either enalapril or placebo. The average follow-up was 32 months. High jugular vein pressure or a third heart sound was found by physical exam on entry into the trial. The risks for worsening heart failure, hospitalization, and death from pump failure were compared in patients with these findings and in patients without these findings. RESULTS Elevated jugular vein pressure was linked to increased risk of hospitalization for heart failure, death or hospitalization for heart failure, and death from pump failure. The presence of a third heart sound was linked to similar higher risks for these outcomes. CONCLUSIONS In CHF patients, elevated jugular vein pressure and a third heart sound are each independently linked with bad outcomes, including progression of heart failure. Looking for these findings with physical exam is clinically meaningful. Source: N Engl J Med. 2001;345(8):574-581 8/23, 2001 Number 8 Title: Prognostic Importance of Elevated Jugular Venous Pressure and a Third Heart Sound in Patients with Heart Failure Authors: Mark Drazner, J. Rame, M. Phil, Lynne Stevenson, Daniel Dries E-mail: mark.drazner@utsouthwestern.edu