All concepts, explanations, trials, and studies have been re-written in plain English and may contain errors. I am not a doctor ----------------------------------------------------------- Fractional Shortening (FS) Shortening fraction is a measure of left ventricular function, although it has the limitation of being dependent on left ventricular loading. For example, a reduction in left ventricular afterload (as in mitral valve insufficiency, ventricular septal defect or peripheral vasodilation) increases ventricular shortening so it increases fractional shortening - even though heart function is not better. Using calculated end-systolic volume index (ESD3/m2) has been suggested as more accurate because it is less influenced by preload. Percent of fractional shortening = difference between end-diastolic and end-systolic dimensions divided by end-diastolic dimension. FS or Fractional Shortening in percentage = EDD minus ESD divided by EDD times 100, where EDD = LV End Diastolic Dimension and ESD = LV End Systolic Dimension Average FS = 36% ; Range = 34 to 44%.