All concepts, explanations, trials, and studies have been re-written in plain English and may contain errors. I am not a doctor ----------------------------------------------------------- NOTE: You can make the print bigger with the font button on your browser! (It's usually a big "A") ----------------------------------------------------------- BACKGROUND The size of the heart as measured by cardiothoracic ratio on chest x-ray is often used to screen for CHF and to estimating its severity. METHODS We compared cardiothoracic ratio (CTR), left ventricular ejection fraction (EF) from MUGA and left ventricular size from ECHO in 91 patients (average age 60 years) with a diagnosis of chronic CHF. RESULTS There was a weak relation between CTR and LVEF and fractional shortening by echo. EF and fractional shortening were more closely linked. No measure of left ventricular function correlated with exercise capacity as measured by peak oxygen consumption (Vo2max). For the group of patients with normal fractional shortening (17 patients), the left ventricle was enlarged in all but 2 (average end diastolic dimension 5.9 mm or 0.7 cm). The two patients with normal dimensions had a low EF. For the 12 patients with a normal CTR, the left ventricular end diastolic size was only slightly smaller than for the rest (6.2 mm or 0.9 cm versus 6.9 mm or 1.2 cm). CONCLUSIONS Chest x-ray is not a reliable indicator of the degree of left ventricular dysfunction. Echo and MUGA are more appropriate for testing heart function. Title: Unreliability of cardiothoracic ratio as a marker of left ventricular impairment: comparison with radionuclide ventriculography and echocardiography. Authors: Clark AL, Coats AJ Source: Postgrad Med J 2000 May;76(895):289-91 PMID: 10775282, UI: 20237872