All concepts, explanations, trials, and studies have been
re-written in plain English and may contain errors. I am
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June 12, 2006 - In patients with weak left heart function but
no CHF symptoms, using the endothelin blocker enrasentan
may actually worsen the heart.
	Researchers compared enrasentan to the ACE
inhibitor enalapril (Vasotec) in 72 patients with left heart
dysfunction but no symptoms.
	Enrasentan patients had heart size increase,
while enalapril patients had heart size go down. Both
groups improved BNP level, but the improvement was
more in the enalapril patients.
	So even though high endothelin levels in CHFers
cause bad effects, at least this one endothelin blocker does
not help at all to slow down CHF onset in patients with
weakened hearts. 
	Go figure.

Source: Heart 2006;92:798-803.
Source: Reuters Health