Target Drug Doses


The target dose is the dose which gave the most proven benefit in clinical trials. Target dose remains the same whether you take one drug or five. For example, if you already take an ACE inhibitor, the target dose for an added ARB would be the same as if you were not taking the ACE inhibitor too.

Patient Tolerance

If you can tolerate it, all your heart failure meds should be raised to the target dose, because that is the dose proven to give the most benefit to the most patients with your illness. However, the same drug will affect people differently - that's a fact. If you cannot tolerate all your meds at target dose, you and your doctor must decide which drugs will give you the most benefit. Those drugs should then be raised to the target dose while other drugs - which may provide less benefit to you in your specific situation - are kept at lower doses. This is another reason it pays to have a good CHF specialist.
     For instance, if you have low blood pressure and cannot tolerate target doses of both Coreg and an ACE inhibitor, your ACE inhibitor dose may be lowered and your Coreg taken to target dose. Why? Because a Coreg target dose has been shown in trials to reduce mortality more than an ACE inhibitor.
     If you then tolerate the target dose of Coreg well, perhaps your ACE inhibitor can slowly be raised again to see if you can also tolerate it at target dose.

You're The Boss

Of course, patients are in charge of their own treatment in the end. After all, it's our body and our health. I have talked it over with my own CHF doc and at my request we've kept my ACE inhibitor dose high (40mg Monopril daily) and my Coreg dose under target levels (15.5mg BID - I weigh 200 pounds). I want it that way because certain side effects of Coreg at higher dose are not worth the reduction in mortality risk to me. It's my call. My doc disagrees but like I said, it's my body.
     Please note: My CHF specialist flatly stated that if I went under 6.25mg Coreg BID, I could find myself another CHF doctor. He also said that I had better seriously consider a minimum dose of 12.5mg BID. He has - as usual - sound reasons for his medical opinions and I take him very seriously. After all, I pay him for his judgment as well as his medical skills. You are in charge of your treatment - but you must pay attention to what your doctor is telling you!

CHF Drug Target Doses

These are not absolutes. Your CHF specialist may choose a different starting dose or a different target dose for you based on your individual health and physical condition. These are pretty good general figures though. This is not intended to be a comprehensive list. Some drugs are not listed. Click on drug or drug class names in the table below for drug trial summaries.

Drug class Brand name
generic name
Starting dose Target dose
ACE Inhibitor Prinivil or Zestril
lisinopril
5 mg once daily 20 mg once daily maximum dose might be 40 mg once daily
ACE Inhibitor Monopril
fosinopril sodium
10 mg once daily
5 mg if weak kidneys
40 mg once daily
ACE Inhibitor Vasotec
enalapril maleate
2.5 mg BID 20 mg BID maximum dose might be 40 mg BID
ACE Inhibitor Mavik
trandolapril
one mg once daily 4 mg once daily
ACE Inhibitor Capoten
captopril
25 mg 2 to 3 times a day 100mg TID (450 mg per day maximum)
ACE Inhibitor Lotensin
benazepril
5 mg once daily if on diuretic
10 mg once daily if not on diuretic
40 mg per day in one 40 mg dose or two 20 mg doses
ACE Inhibitor Accupril
quinapril
5 mg BID
2.5 mg BID if weak kidneys
20 mg BID
ACE Inhibitor Altace
ramipril
1.25 mg to 2.5 mg BID 10 mg BID
ACE Inhibitor Aceon
perindopril erbumine
1 mg BID if on diuretic
2 mg BID if not on diuretic
4 mg BID (8 mg BID maximum)
ARB Cozaar
losartan
25 mg BID or 50 mg once daily
12.5 mg BID or 25 mg once daily if weak liver function
50 mg BID
ARB Atacand
candesartan cilexetil
4 to 8 mg once daily 32 mg once daily
ARB Diovan
valsartan
80 mg once daily 160 mg once daily 80 mg once daily if weak liver function
ARB Avapro
irbesartan
150 mg 300 mg once daily
Beta-blocker Coreg
carvedilol
3.125 mg BID 25 mg BID under 188 pounds 50 mg BID over 187 pounds
Beta-blocker Toprol XL
metoprolol extended release
12.5 mg for class 3 to 4 patients
25 mg for class 1 to 2 patients
190 mg once daily
Beta-blocker Zebeta
bisoprolol
2.5 mg once daily 10 mg once daily
  Aldactone
spironolactone
25 mg once daily 25 mg once daily
See this article
  Inspra
eplerenone
25 mg once daily 50 mg once daily
See this article

All information on this site is opinion only. All concepts, explanations, trials, and studies have been re-written in plain English and may contain errors. I am not a doctor. Use the reference information at the end of each article to search MedLine for more complete and accurate information. All original copyrights apply. No information on this page should be used by any person to affect their medical, legal, educational, social, or psychological treatment in any way. I am not a doctor. This web site and all its pages, graphics, and content copyright © 1997, 1998, 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006 Jon C.

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